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Pathobiology of troponin elevations: do elevations take place with myocardial ischemia and also necrosis?murine knockout designs. cTnT-knockout triggers sarcomere disassembly and early embryonic lethality.18 Remarkably, knockout of cTnI in murine embryos has no effect on wellbeing before postnatal day fifteen, attributable to ssTnI compensating for